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5, 7
5, or 10 g androgel (t gel) 1% ciii per day for up to 42 months
efficacy data were presented in 123 subjects considered evaluable
continuous androgel treatment normalized mean serum t and free t levels
mean serum 5α-dihydrotestosterone concentrations and 5α-dihydrotestosterone/t ratio slightly increased, mean serum estradiol/t ratio doubled, and mean. serum fsh and lh levels were suppressed by t replacement
sexual function and mood parameters improved rapidly and were maintained throughout t treatment
lean body mass increased (p = 0
0001) and fat mass decreased (p = 0
0001), and these changes were maintained with treatment but were not accompanied by significant increases. in muscle strength
increases in serum bone markers suggestive of increased bone formation were followed by gradual and progressive increases in bone mineral density more in the spine (p = 0
mild local skin irritation occurred in 12 subjects, resulting in discontinuation in only one subject
except for the anticipated increase in hematocrit and hemoglobin, there were no clinically significant changes in blood counts or biochemistry
in three subjects with elevated serum prostate-specific antigen, prostate biopsies showed cancer
we conclude that continued application of androgel resulted in beneficial effects similar to those with injectables and other transdermal preparations
this study was neither placebo controlled. nor powered to determine the effects of t treatment on prostate cancer risk
thus, monitoring for prostatic disease and assessment for erythrocytosis are strongly advised to reduce the risk of adverse events with t treatment of hypogonadal men
we previously demonstrated that testosterone (t) gel (androgel t gel 1% ciii, solvay pharmaceuticals, marietta, ga) provided steady serum t concentrations within the physiological range with proportional increases in serum free t, 5α-dihydrotestosterone (dht), and estradiol (e2) concentrations (1, 2)
for simplicity, androgel will be used throughout this manuscript
over 150 hypogonadal men who received the androgel replacement for

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and no castlevania
nintendo plans to add three nes games to the service each month over the next three months, with metroid coming in november and ninja gaiden coming in december
the selection is still anemic and woefully incomplete, even just for nes classics
the complete lack of snes games is even more baffling, considering how many excellent first-party games came out on that system
the game emulation is capable and responsive, reminiscent of the nes classic’s emulation in feel and visuals
the sprites are bright and colorful, the picture is crisp, and the options are very limited
you have a choice of three different display modes: 4:3 (a slightly wider than originally built pillar-boxed view with no filter), pixel perfect (a narrower pillar-boxed view that keeps the native aspect ratio by pixel count), and crt (a heavy scanline filter over the 4:3 view)
you also can’t remap your controls from the default layout in any way, choose between different regional versions of the games, or look up any supplemental material (even a game’s instruction manual, aside from a short text summary and a screenshot)
multiplayer support, however, is surprisingly robust for a collection of nes games
you can play locally with one or two players using joy-cons, or you can play online with friends
for all the baffling decisions and disappointing limitations of nintendo switch online, all of the features of the service function exactly as intended
i played some super mario bros
3 online with a colleague, using voice chat through the nintendo switch online smartphone app
while setting up the voice chat was unwieldy because of the need to balance my phone’s chat audio with the switch itself, actually setting up a two-player nes game online was as easy as opening the game in online mode and waiting until my colleague saw it pop up on his switch
once the game was loaded, i could interact with it as the first player and my colleague could interact with it as the second player, as if he had a controller plugged into the second port on an nes
we could also control on-screen pointers using the right analog stick, indicating things on the screen and performing a clapping action when clicking the stick in
it’s a friendly gesture that limits negative interaction in theory, but i can see condescending applause ensuing for every embarrassing mistake you make when playing with a friend
3 felt very responsive on both of our systems
despite the implementation issues, voice chat also worked very well
audio sounded clear on both of our ends, with less than a second of lag, enabling consistent conversation
i used the app with a set of bluetooth earphones, while he used wired earphones
of course, the exact same dynamic, perhaps with better performance and many more configuration options, could have been achieved as easily with discord, google duo, skype, or any other voip or voice chat app; the use of the nintendo switch online app isn’t necessary at all for communication, since you’ll be using your smartphone regardless
integrating voice chat into the switch itself and using the headphone jack or bluetooth would have been much easier to set up and use
nintendo switch online succeeds at everything it tries to do
its problem is that it doesn’t try to do enough, and the things it tries to do are perplexingly limited or so convoluted that they’re useless
online multiplayer is good, but switch owners had it free for a year and a half before nintendo began charging for it
cloud saves are good, but not all games support them
voice chat works, but requires using a smartphone instead of going through the switch
and the classic nes games could be the start of an appealing netflix-like library of classic games, but right now the selection is so tiny as to be nearly useless
nintendo switch online’s saving grace is its $20 annual price tag, which is much easier to swallow than the $60 prices of ps plus and xbox live gold
if you want to play online multiplayer on the switch, you have no choice but to subscribe
still, for voice chat, you should stick with discord, and for classic nes games, you should stick with the nes classic or dust off your wii u or 3ds
nintendo switch online is a very nintendo-like mess, mixing some interesting ideas with baffling execution
bottom line: nintendo switch online is a necessary subscription if you want to play switch games online
how it implements its various features, though, is baffling and frustrating
will greenwald has been covering consumer technology for a decade, and has served on the editorial staffs of cnet
com, sound & vision, and maximum pc
his work and analysis has been seen in gamepro, tested
com, and several other publications
he currently covers consumer electronics in the pc labs as the in-house home entertainment expert, reviewing tvs, media hubs, speakers, headphones, and gaming accessories
will is also an isf level ii-certified tv calibrator, which ensures the thoroughness and accuracy of all pcmag tv reviews
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how to turn off motion smoothing on your tv
hisense 100-inch 4k ultra hd smart dual color laser tv (100l10e)
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kayo the sports streaming app has launched in australia
a revamped media browse layout with

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