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dans la prostate
liaison du ligand aux androgènes l’action des androgènes passe par de nombreuses étapes
le ra non lié, probablement situé dans le cytoplasme, est maintenu dans un état conformationnel favorable à la liaison avec un androgène par les protéines de choc thermique [28, 53, 129]
seule la fraction libre de la testostérone entre dans la cellule cible des androgènes par diffusion
elle se lie alors au récepteur (ra) directement ou après sa transformation irréversible par la 5a-réductase isoforme de type 2 (srd5a2) [150] en. son métabolite plus actif, la 5a-dihydrotestostérone (dht)
la liaison hormone-ra conduit à la dissociation des protéines du choc thermique (hsp), suivie d’une phosphorylation et d’un changement de configuration allostérique du récepteur [95] qui se combine à un autre pour former un dimère
celui-ci est alors stabilisé dans le noyau et se fixe par ses domaines de liaison à des séquences spécifiques de l’adn, les éléments de réponse aux androgènes (androgen response elements ou ares) [31, 157]
l’homo-dimère rassemble des molécules additionnelles dont :

1
des. co-facteurs type co-activateurs : tels src-1 (steroid

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from nintendo network services
these videos can either be downloaded to the system’s permanent storage through spotpass or streamed over the user’s internet connection
on the nintendo 3ds, many of these videos are offered in 3d; on the wii u, only 2d videos are available
the exact content available varies by region
future plans include bringing netflix outside of north america to the united kingdom and ireland with a selection of full-length 3d movies[62] and hulu plus to nintendo 3ds
nintendo also planned to bring other video on demand and dvr services to wii u through nintendo tvii
nintendo tv is a video gaming online magazine published by future publishing for nintendo network
it is produced by the team behind the official nintendo magazine and features video reviews and previews and footage of upcoming and recently released nintendo games
episodes are released monthly on the nintendo eshop, nintendo channel and youtube where users can watch all the latest news, reviews and previews of wii, wii u, nintendo ds, nintendo 3ds and virtual console games
[63] this series is exclusive to pal region consoles
nintendo show 3d was a video gaming online show produced by nintendo and hosted by jessie cantrell
it featured video previews and footage of upcoming and recently released nintendo 3ds retail and digital game titles
episodes were released every two weeks on the nintendo eshop free of charge
this series was exclusive to north american nintendo 3ds consoles
[64] nintendo show 3d released its last episode on march 28, 2013
the nintendo eshop offers a wide range of downloadable video content for the nintendo 3ds
these videos are mostly offered in 3d, and are downloaded right to the system’s memory
in order to produce and distribute these short films nintendo has partnered with companies such as breakthru films, black box productions, atlantic productions, ka-ching cartoons and dreamworks animation
in the future, nintendo also plans to expand this video distribution service to even larger companies like dreamworks, bringing exclusive content to nintendo 3ds and wii u owners
nintendo has stated that nintendo network will provide the means for users to chat via text, voice, and video
all three means of chatting will be available on the wii u through its wii u chat and miiverse services
[66] on the nintendo 3ds, the swapnote (nintendo letter box) application allowed users to send handwritten notes, pictures, and sound to one another through the nintendo network, powered by the spotpass delivery service
[67] users will also be able to globally communicate with one another through the miiverse social network service
swapnote[e] is a messaging application for the nintendo 3ds
swapnote was released on december 22, 2011 in europe, australia and north america via the nintendo eshop, and can be downloaded at no additional cost, and is pre-installed on newer systems
this application allows users to send hand-written/drawn messages to registered friends via spotpass either or other users via streetpass
[68] the app also allows users to freely embed pictures and sounds into their messages, and it also lets users change the position and the orientation of the picture and sound icons
features are unlocked as players continue to send letters, such as the ability to hand-write/draw 3d messages, with additional stationary and features unlocked by spending play coins
messages sent and received can also be saved indefinitely, in spite of the 3000 message limit
additional stationary can be obtained via certain nintendo related events, such as using specific software, or by saving them from other people’s messages
on october 31, 2013, nintendo abruptly suspended the swapnote/nintendo letter box spotpass functionality after discovering minors were sharing friend codes with strangers who had exploited the messaging service to allegedly exchange pornographic imagery
[69][70] additionally, the special notes service, which were also sent via spotpass to promote nintendo games, has also been suspended
nintendo issued an apology to those who had been using the application in a responsible manner
without any prior notice, nintendo released a messaging application for the nintendo 3ds in november 2016 entitled swapdoodle[f]
regarded as a spiritual successor to swapnote/nintendo letter box, the app supports the exchange of 3d messages between users online using only spotpass, albeit user content is limited to drawings, handwritten text, icons, and native in-game screenshots
additionally, swapdoodle has access to an in-app dlc store, allowing users to purchase bundle packs that include additional pens, ink units, stationery, message space, and drawing lessons
wii u chat was wii u’s online chat solution, powered by nintendo network
[73] the service allowed users to use the wii u gamepad’s front-facing camera to video chat with registered friends
while video chatting, only the wii u gamepad is needed, since on the tv, the same picture as in the gamepad’s is shown
users could have also drawn on the gamepad during a chat session
if there is a game or another application already running, the wii u gamepad’s home button ring will flash indicating that there is an incoming call
the idea of the feature was originally seen in the introduction trailer of the wii u in e3 2011
however, users weren’t also able to use the service as a multitasking application, therefore not having the ability to make video calls without interrupting game play
nintendo had announced a desire to make video chat possible through multitasking,[75] but it was never implemented
wii u chat was deployed in the wii u’s launch day firmware update
the feature was discontinued worldwide on november 8, 2017 at 3:00 pm jst
the nintendo 3ds internet browser is an internet

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