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à un ion zinc portent le nom de « zinc fingers » [55]
cette structure est commune aux différents récepteurs des stéroïdes [56]
le premier doigt est responsable de la reconnaissance de la séquence de l’adn-cible, trois amino-acides à sa base étant particulièrement critiques (glycine, serine, valine) [13, 175]
cette association de trois amino-acides, également présente dans les autres récepteurs des stéroïdes, entre en contact direct avec les éléments de réponse hormonale (hres) des gènes-cibles
le second doigt, très basique,. favorise la formation de l’homodimère [23] et stabilise l’interaction adn-récepteur [133]
il serait impliqué dans les changements conformationnels entraînés par la liaison avec les androgènes et les anti-androgènes [88] et est porteur d’un site de phosphorylation nécessaire pour une activité transcriptionnelle optimale du ra [205]
en l’absence du ligand, le ra est localisé dans le cytoplasme alors que l’activation par un androgène entraîne sa translocation rapide dans le noyau au travers des pores nucléaires, débutant en quelques. minutes et apparement complète en 30 minutes [79]
une séquence située à la jonction de la région charnière et du domaine de liaison à l’adn est responsable du signal de transfert [206]
ce domaine serait aussi responsable d’interactions avec des protéines

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it allows users to play together through the internet
users on the nintendo 3ds can currently play with one another by entering their friend’s universal friend code into the nintendo 3ds’s friends roster
alternatively, supported games can allow users to play on the internet without having to enter any friend codes, this feature is called online communities, and it debuted in mario kart 7
the process of online multiplayer is further streamlined through the use of a unified user account system first available during the launch of the wii u andlater brought to the nintendo 3ds
the user account system would eliminate the need to enter friend codes; instead, users can enter one another’s user accounts
nintendo network also allows users to share rankings and to review the ranks of others
software updates, more commonly known as patches, have been available on both nintendo 3ds, since april 25, 2012,[17] and wii u, since november 18, 2012,[18] via a system update
these system updates gave the ability to patch downloadable titles, as well as retail games, through both the nintendo eshop and home menu
these patches have the main purpose of fixing security vulnerabilities and other bugs, and improving the usability or performance
patches can also be downloaded while using other applications via the systems’ download manager
the nintendo eshop[b] is an online marketplace powered by nintendo network
the eshop allows users on the nintendo 3ds and the wii u to access and purchase exclusive digital games, virtual console games, and certain retail games
moreover, users can obtain patches and additional downloadable content for digital downloads; in-game purchases are also supported
before purchasing a piece of software, the eshop allows users to view ratings, screenshots, and videos pertaining to that piece of software
developers can also release demos of both digital and physical games on the eshop
currently, purchases made through the nintendo eshop on the nintendo 3ds are tied to the system that they were purchased from, and they can only be transferred by contacting nintendo’s customer service
however, nintendo has stated that this will change with the launch of the wii u and the nintendo network user account system
on the wii u, the user’s purchases are tied to their nintendo network account but they cannot be transferred to other systems by the user as the nintendo network account is tied to a specific console
this user account system was added to the nintendo 3ds via a system update on december 9, 2013, coinciding with miiverse being added to the system, allowing players to combine their funds with their wii u account
most wii u and nintendo 3ds retail software titles are available to download via the nintendo eshop
the first of these titles was new super mario bros
2 for the nintendo 3ds, which launched on the nintendo eshop alongside its retail release in august 2012
add-ons include downloadable content, addition of new features, and patches
add-on software can be added to both digital and physical games
game demos of retail and digital games have been available free to download on the nintendo eshop since it was updated in december 2011
[23] developers are required to limit the number of plays available to the user
[24] the first paid demo was released in japan on august 4, 2011[25] and free demos were released in japan on december 27, 2011[26] and in north america on january 19, 2012
virtual console[c], sometimes abbreviated as vc, is a specialized section of the nintendo eshop online service that allow players to purchase and download games from discontinued consoles and other software for nintendo’s wii, wii u, and nintendo 3ds
the wii u uses the wii u menu and nintendo eshop to access and purchase virtual console titles, respectively
virtual console games on the wii u can be suspended and users can also create save states anytime
all virtual console game bought on the nintendo eshop can be played on the gamepad through off-tv play
the entire virtual console library available on wii is also available on wii u, but only through the implementation of the console’s « wii mode » and wii shop channel, to access and purchase virtual console titles
the nintendo 3ds uses the home menu and nintendo eshop to access and purchase virtual console titles, respectively
virtual console games on the nintendo 3ds can be suspended and users can also create save states anytime
planned future releases will include purchasing software from the neo-geo and turbografx-16 libraries
[citation needed ] special features in this interpretation of the virtual console allow players to create restore points, temporarily saving the game state for use later, and the optional ability to view games in their original resolution accompanied with special borders
miiverse[d] was a social network for wii u and nintendo 3ds, created by nintendo system development and hatena, and powered by the nintendo network
it was discontinued on november 7, 2017
[28] integrated into every game, miiverse allowed players to interact and share their experiences through their own miis by way

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