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de même pour le domaine nh2 terminal qui possède un allongement polyglutamine de longueur variable
cet important domaine du ra représente plus de la moitié de la protéine
il intervient de façon prédominante dans la régulation de la transcription [78, 159] la totalité du domaine est. requis pour une action complète du récepteur [46, 67]
unezone fonctionnelle spécifique, dénommée af-1 et regroupant deux régions à fonction puissante appelées t-1 et t-5, possède toutefois un pouvoir activateur de la transcription particulièrement marqué [78]
l’interaction entre le domaine amino-terminal et le domaine de. liaison du ligand carboxy-terminal est responsable de la conformation tridimensionnelle stable du récepteur [93]
le domaine amino-terminal est porteur d’une chaîne polymorphique de résidus glutamines codé par une répétition polymorphe (cag)ncaa [204]
dans la population normale, le nombre de résidus glutamine varie de 9 à 38 [36] et rend compte du polymorphisme du gène du ra
dans ce domaine situé au centre du récepteur, 2 anses protéiques maintenues à leur base par 4 résidus cystéine liées

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a user account system on the wii u), spotpass, and eshop
[2] during the pre-e3 nintendo direct, nintendo clarified that nintendo network would be the basis for nintendo’s new social network known as miiverse
[3] nintendo network will provide the network infrastructure for the nintendo 3ds, for the wii u, and was initially planned for future nintendo platforms
^[a]the miiverse app was made available on the nintendo 3ds on december 9, 2013
nintendo network previously provided legacy support for the wii and nintendo ds/dsi systems since nintendo wi-fi connection which had been absorbed into the service
this had ensured the uninterrupted online support and general backwards compatibility of the legacy wii and ds families of game libraries when played on the current wii u and the nintendo 3ds
the free nintendo wi-fi connection service was globally discontinued on may 20, 2014, which ceased support for online multiplayer, matchmaking, and leader boards for wii and nintendo ds games that supported those features, and this also applies to the legacy online support of these games when played on wii u and nintendo 3ds, including downloadable versions
the wii shop channel and the « pay & play » game variants have not been affected at this time
the nintendo dsi shop closed on march 31, 2017, but dsiware available on the nintendo eshop will be unaffected
nintendo network ids are user account systems for the wii u and nintendo 3ds, which allows players to access certain online features such as the nintendo eshop and miiverse
as of december 9, 2013, nintendo network ids were implemented onto the nintendo 3ds, becoming required for downloading free demos from the eshop, replacing the previous system in which eshop purchases were tied to a single system
players who own both a wii u and a nintendo 3ds are able to link a single nintendo network id to both systems, allowing funds added from credit cards or pre-paid cards to be shared across both systems’ eshops
however, a nintendo network id can only be used on one 3ds system at a time, requiring players to perform a system transfer to move account details from one 3ds system to another (ids are currently tied to a single wii u system, though a future update to resolve this has been promised, which is also essential for the company’s long-term plans[14])
players may also sign into nintendo network on other platforms, such as the web-based miiverse portal for computers, with functionality for tablets and smartphones also planned
nintendo originally planned for the nintendo network id to become a prominent account system standard for all future nintendo hardware releases, as well as any nintendo-published apps released for non-nintendo devices
[14] however, in march 2016, nintendo introduced nintendo account for non-nintendo devices and the nintendo switch, although the new account service compliments nintendo network id if users have one
for example, if users link their nintendo network id to their nintendo account, they can share eshop funds between their nintendo switch and their wii u/nintendo 3ds
nintendo network currently uses a universal friend code system as its account system for the nintendo 3ds
while these friend codes can only be registered for one user per system, they are functional for all nintendo 3ds software used on that system
these friend codes are still tied to a single system and initially had limited transference under a conditional online protocol
after the nintendo network id (nnid) has been introduced for the nintendo 3ds in december 2013, the limit on system transfers has been waived, but both nnid accounts and friend codes remain tied to a single system at a time
in japan, the first games to introduce nintendo network officially were theatrhythm final fantasy and tekken 3d: prime edition, which were both released on the same day in february 2012
the first game that officially introduced the nintendo network outside japan was kid icarus: uprising, released in march 2012
most games that were released with nintendo wi-fi connection support prior to the launch of the nintendo network were later rebranded as nintendo network compatible games, including nintendo 3ds launch titles such as nintendogs + cats
nintendo network compatible games launched alongside the wii u in 2012
ubisoft has confirmed that assassin’s creed iii and marvel avengers: battle for earth would launch with nintendo network support
one key feature of nintendo network is that

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