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aussi dans le coeur, le muscle et le foie, alors que les concentrations dans les autres tissus androgéno-sensibles, comme l’os par exemple, sont beaucoup plus basses
ce facteur de transcription dépendant d’un ligand(ici la testostérone ou la dht) appartient à la super-famille des récepteurs nucléaires qui comprend le récepteur des hormones stéroïdes (récepteur aux androgènes [ra], récepteur. à la progestérone [pr], récepteur aux glucocorticoïdes [gr] et récepteur aux minéralo-corticoïdes [mr]), des hormones thyroïdiennes, de la 1-25 di-hydroxy-vitamine d et les récepteurs de l’ecdysone et des proliférateurs des peroxisomes activés [138, 207]
de plus, de nombreuses protéines nucléaires ont une structure analogue au récepteur nucléaire sans ligand identifié (récepteurs orphelins)
des analyses comparatives de la. structure et de la fonction des récepteurs stéroïdes nucléaires ont montré une grande homologie avec une organisation structurale commune comprenant quatre domainesdifférents : domaine de transactivation nh2 terminal, domaine de liaison à l’adn, domaine de liaison du ligand cooh terminal et une région charnière (figure 8)
bien que les domaines soient distincts, ils interagissent entre eux [93]: par exemple, tant que le domaine de liaison du ligand n’est pas occupé par un androgène, il bloque la transactivation par le domaine amino-terminal qui lui-même empêche la liaison avec l’adn [133]
l’interaction entre les extrémités amine et carboxyl est nécessaire à la stabilisation du ra activé par un androgène et la disposition spatiale du. dimère ra [14, 92, 93], ainsi qu’au recrutement des protéines coactivatrices (src1, tif2, cbp) [149]
la forme la plus fréquente du ra est une protéine de 110-114 kda composée de 910-919 acides aminés [79, 189]
les variations de longueur tiennent au nombre variable des répétitions de triplets dans l’exon 1 du gène du ra [32, 33, 101, 102]
en effet, si les domaines de liaison à l’adn et de liaison au ligand domaine ont une très forte homologie, il n’en est pas

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of the nintendo switch online service, and at launch will support splatoon 2, mario kart 8 deluxe, arms, mario tennis aces and the subscription service’s library of nintendo entertainment system games
in select games the app will also allow you to access other special features
right now the only game that supports this seems to be splatoon 2, which gets you exclusive items from a game store only available via the nintendo switch online app
nintendo switch online members will get access to special offers
these could be discounts, in-game items or special products not available to nonsubscribers
so far, there are only two examples of what these kind of special offers might actually be: special in-game gear for splatoon 2 (available to subscribers that pay for a year of service in advance) and nintendo entertainment system controllers for nintendo switch– a product nintendo says will only be sold to subscribers — not in stores
it’s kind of a shame these controllers are available only to subscribers of the nintendo switch online service
they look almost identical to the original nes’ gamepads, save for a joy-con rail on the top edge of the square controller to dock it to the nintendo switch for charging
still, the limited availability makes some amount of sense: they’re designed specifically to be used with the nintendo switch online’s library of classic nes games, which themselves are only available to subscribers
this benefit could be a goldmine for memorabilia collectors in the future, assuming the controllers are any indication of the kind of « special offers » available to subscribers
this is where things get a little complicated
your nintendo switch has individual user accounts for each user
nintendo also has a « nintendo account » to manage your profile and purchase history on the website, console devices and smartphone apps
to use nintendo switch online, you’ll need both
if you already have a nintendo switch, you’ve probably already got this covered, but if you’re new to both switch online and the console itself, you’ll want to head over to http://accounts
just make sure you’re liking your console to the right account — any switch profile linked to a nintendo account will be permanently locked in
don’t want to shell out separate subscription fees for every member of your family? you’re in luck
nintendo is offering a 12-month family membership for $34
every person on the family membership plan should get full access to the nintendo switch online service benefits
not convinced? nintendo knows its service will be met with skepticism
that’s why it’s offering all users a one-week free trial when the service launches sept
the seven-day trial offers almost all the benefits of the core service but won’t include access to special offers, like those retro nes controllers
if you don’t like the service, however, you’ll have to manually disable auto-renewal to avoid being charged a $3
99 monthly fee at the end of your trial
if you started the free trial during its launch week, you’d better check your bill now — it’s probably about renewal time
prepaid subscription cards are available at select retailers, but the easiest way to buy the service is simply try to play a multiplayer game on your switch — it’ll take you directly to the eshop to complete the sign-up process
this post will be updated as more details on nintendo switch online emerge
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voice chat and the nintendo switch smartphone app
you’ll need a nintendo account to sign up
up to 8 nintendo accounts can share a nintendo switch online subscription
discuss: nintendo switch online: your guide to the paid subscription service
you can access the japanese library of retro games, too
the nintendo network[a] is nintendo’s online service which provides online functionality for the nintendo 3ds and wii u systems and their compatible games
announced on january 26, 2012 at an investors’ conference, it is nintendo’s second online service after nintendo wi-fi connection
former president of nintendo satoru iwata said, « unlike nintendo wi-fi connection, which has been focused upon specific functionalities and concepts, we are aiming to establish a platform where various services available through the network for our consumers shall be connected via nintendo network service so that the company can make comprehensive proposals to consumers
nintendo switch does not use nintendo network as its online platform
it instead uses nintendo account, which can be created using either a nintendo network id or social login
multiplayer functionality requires use of the subscription-based nintendo switch online service
on january 20, 2012, an image of theatrhythm final fantasy' s box art was released showing a « nintendo network » icon in the corner of the box
it was speculated that « nintendo network » was a rebranding of the nintendo wi-fi connection
nintendo officially announced nintendo network on january 26, 2012
nintendo stated that nintendo network will be an entirely new unified network system as opposed to a rebranding of nintendo wi-fi connection
nintendo stated that the nintendo network will provide the infrastructure for online multiplayer (through universal friend codes on the nintendo 3ds and

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