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ou glucuro-conjuguée
la dht peut être transformée en androstènediol, à la fois forme de stockage, car la conversion est réversible, et forme d’élimination stéroïdienne
le glucuronide d’androstènediol, mesuré sur un recueil urinaire de 24 heures, sera ainsi un reflet de l’utilisation tissulaire des androgènes
a l’inverse, le glucuronide de testostérone, issu de la transformation hépatique du stéroïde, sera le témoin de la production testiculaire de l’androgène [87]
cet ensemble métabolique est. très actif puisque la 1/2 vie de la testostérone est de 12 minutes, ce qui implique une fabrication permanente par le testicule [141]
lors du vieillissement, on observe une diminution de la clairance métabolique de la testostérone [182], qui résulte de la diminution du débit cardiaque, hépatique et tissulaire et de l’augmentation de la liaison à la shbg
les stéroïdes libres peuvent diffuser aisément jusqu’au noyau des cellules,. mais seules certaines cellules sont capables de les retenir grâce à des récepteurs spécifiques
la testostérone et son métabolite la dht, qui assurent l’essentiel de l’action androgène chez l’homme, peuvent ainsi activer des gènes spécifiquement sensibles qui augmentent l’expression de certaines protéines sous contrôle androgène
bien que la testostérone soit l’androgène prédominant dans la circulation périphérique avec une concentration 10 à 12 fois supérieure à la dht, la concentration tissulaire locale de dht, dont l’action androgène est plus forte, peut être plus élevée
l’action des androgènes sur l’expression génomique passe par un capteur spécifique unique: le récepteur aux androgènes (ra)
le ra est largement distribué dans l’organisme
les concentrations les plus élevées sont présentes dans les organes sexuels (prostate, testicules, ovaires) mais

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because in japan, zelda made its debut on the famicom disk system, an expansion that never made it to the nes outside of its home country
did you know that the japanese version of super mario bros
3 isslightly harder? it is
when mario gets damaged in a tanooki suit, hedrops all the way back down to small mario in that version of the game
we can expect more games with differences, too: metroid, due on the system in november, was also a disk system game
it’s a small bonus, but worth it for fans that want to see how some of these games were changed when they came overseas
access to online multiplayer gaming is the main selling point of most console subscription services
just like with xbox live and playstation plus, subscribing to nintendo switch online allows you to play games like mario kart 8 deluxe, arms and splatoon 2 and the upcoming super smash bros
and, as mentioned above, online play is also enabled for the nintendo switch online service’s library of classic games — just in case you want to relive the torture of waiting for player 1 to die before taking your turn in super mario bros
at least one favorite online multiplayer game will work without a subscription
fortnite  will be playable onlineeven if you don’t have an active online subscription
there may be other exceptions to the rule, presumably for games that feature online multiplayer exclusively
nintendo hasn’t made a full list available yet
if you wanted to back up your save data on a nintendo wii, wii u or 3ds, you needed to transfer it to an sd card
on the nintendo switch, that isn’t an option
if your system is lost, stolen or broken, all the hours you sunk into the legend of zelda: breath of the wildwill be lost forever
nintendo switch online’s save data cloud feature aims to change that
for nintendo switch online subscribers, game data will automatically be backed up to nintendo servers if you have an internet connection
if you sign in to your account on a new console, you’ll be able to download that data and pick up right where you left off
it’s an easy, simple way to protect the time you’ve invested in nintendo switch games
unfortunately, there’s a catch
in order to prevent save scumming and cheating in online games, certain titles aren’t compatible with this feature
on the surface, that seems to make sense — we can’t have players hacking their pokemon let’s go: pikachu and eevee save data to cheat — but it means that competitive multiplayer games with a single-player component aren’t protected
if you lose your switch and want to pick up where you left off in splatoon 2’s single-player campaign, for instance, you’ll be out of luck
nintendo also says it can’t guarantee the data will stick around if you cancel your subscription
early wording on how long the data stuck around was frustratingly vague
recently, the company clarified: explaining to ign that if you cancel, you have six months to resubscribe before your cloud data is potentially deleted
that’s the same amount of time sony gives playstation plus users
online multiplayer is great, but without the ability to talk to other players, it’s a weirdly solitary social experience
that’s why voice chat is so important
unfortunately, nintendo’s solution to voice chat is
most game consoles allow you to plug a headset into the console’s usb port or audio input jack and talk to players directly through the game
but most nintendo switch games that support voice chat require the user to piggyback off of a smartphone by using the nintendo switch online smartphone app
it’s a convoluted and weird experience
to chat with other players in splatoon 2, for instance, you’ll need to download the app on your phone , invite your friends to a skype-like voip chat in the game, then fire up the app and, finally, connect to your match
you’ll be talking with your team on your smartphone while playing the game on your console
at least the most recent update made it a little better — at least in certain games
if you start a multiplayer session in the new retro nes app, the switch online app will automatically detect your play session and connect you to your friend
some games will even let you chat with other players who aren’t on your friend’s list: after a recent updates mario kart 8, will tell you that other users are in voice chat, prompting you to find and open the app
it’s still a weird speakerphone chat solution, but at least you don’t need to create the room for yourself
in a recent nintendo direct, the company praised the system as being more open, a way for other people in the room to hear and talk on the voice chat via speaker phone
if you want to have a traditional console experience, you’ll need to buy a complicated audio splitter to literally tether your switch to your smartphone
it isn’t a user-friendly experience, which is why some games have already sidestepped it
want to use voice chat in fortnite on nintendo switch? simply plug a headset into the console and play
despite how much better that is, nintendo is still doubling down on app-based voice chat
it’s part

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