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les voies de dégradation des androgènes dépendent du profil enzymatique local
la majorité des réactions cataboliques se font dans le foie, mais aussi dans la peau et la prostate pour aboutir à une élimination dans l’urine ou par la peau
c’est la testostérone elle-même qui induit les enzymes hépatiques responsables de son propre catabolisme
la plupart des métabolites sont inactifs, mais des exceptions sont possibles (métabolites 5b-androgènes qui stimulent la formation de l’hème dans la. moelle osseuse et le foie [15])
la testostérone est convertie en androgènes faibles et inactifs : dhea (androgène surrénalien faible), androstérone (par 5a-réduction hépatique) et étiocholanolone (par 5b-réduction hépatique) éliminés dans l’urine et la bile
l’androstérone et l’étiocholanolone (17-cétostéroïdes) sont les métabolites urinaires les plus abondants
certains métabolites des androgènes sont excrétés sous forme de stéroïdes libres, d’autres sous forme sulfo

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with the service, and most of them are classics
day one subscribers have access to games like super mario bros
3, the legend of zelda, balloon fight, donkey kong, double dragon and river city ransom
in october, nintendo will add solomon’s key, nes open and super dodge ball to the library
in november and december it will follow up with metroid, wario’s woods and other games
to play them, you’ll need to download the « nintendoentertainment system — nintendo switch online »app from the eshop
yes, that name is a mouthful, but it’s also exactly what it sounds like
the game interface is pretty much a wallpaper spread of classic video game box art
select one, and you’ll be instantly dropped into the game
if you played nintendo’s miniature nes classic console, you’ll feel right at home – in our tests the emulation and visual quality felt about on par with the throwback console
it even has the same filters: drop into the menu and you can select between a 4:3 mode, pixel perfect and a fuzzy scanline-filled crt mode
even so, this is more than the nes classic repackaged as an app
nintendo has also tacked on an online multiplayer mode – letting you pass the second player controller to a friend over the internet
it’s one of those ideas that’s so silly, it’s actually pretty novel: these games were created before the internet was even a thing
now you can play them online
being able to play river city ransom online with a friend is neat, but the execution has its flaws
games that don’t have multiplayer built in aren’t amazing: allyou can do is trade who has control of the game
player 2 will just haveto watch, or point to things with an online cursor
setting up a game or joining a friend is easy enough – you just select the multiplayer mode, select your friend’s name, and play – but the experience is pretty sensitive to shoddy internet connections
when it works, it’s a blast, but throw in even a tiny bit of lag and the experience quickly becomes a mess of input delay and game slowdown
there are a few other quirks, too
if you want change to use save states to record your progress or change to a different game, you’ll have to press the l and r triggers on your controller
that’s a bit unintuitive, and easy to do by accident
still, if you don’t have an nes classic, it’s a nice way to get your retro fix on nintendo switch
better still, nintendo is planning to add more games to the library each month – and has already announced nine more titles coming to the service by the end of the year
nintendo hasn’t announced the full list of games it’ll add to the service in 2019, but here’s every nes title coming to the nintendo switch online that’s been announced so far:
these are the games nintendo will add to the service in the coming months:
naturally, you’ll lose access to the games if you let your nintendo switch online subscription lapse
but you should know that you’ll also lose access to your nes library if your console is disconnected from the internet for more than a week
nintendo says the console needs to check in with the service every seven days to maintain access
that isn’t an issue with games downloaded from xbox live’s games with gold or playstation plus
not content with the nes library of classic games? if you’re willing to jump through a couple of hoops, you can get a few more options
this is a little convoluted, but bear with us: players who make a second nintendo account and assign it « japan » as the region can create a second profile on their switch with access to the japanese eshop
this will let you buy and download any game released digitally in japan — including the « family computer » nintendo switch online app
basically, it’s the exact same thing as the nes app detailed above, but filled with japanese games
most of the games on the family computer app are the same as on its international counterpart, but there are a few key differences in some titles
the japanese version of the legend of zelda, for instance, has a more complex soundtrack — offering richer music with more audio channels and instruments than the us version
that’s

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