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le contrôle des cellules de leydig et le début de la stéroïdogenèse seraient sous la dépendance d’un autre mécanisme [140]
dans la période néo-natale, l’action des gonadotrophines amène les taux de testostérone au niveau de ceux observés durant la puberté, puis les cellules de leydig régressent
durant la puberté, l’augmentation des taux de. lh entraîne une deuxième phase de prolifération et de différentiation conduisant au nombre de cellules de leydig de l’adulte [148]
la diminution de la testostérone liée à l’âge est pour partie liée à l’atrophie progressive et à la disparition des cellules de leydig mais également au déclin des capacités de stéroïdogenèse. [125]
la fonction principale des cellules de leydig est la production d’androgènes, mais elles produisent également de l’igf-1 et des facteurs de croissance qui interviennent dans la régulation autocrine et paracrine du testicule [141]
l’hypothalamus siège à la base du cerveau juste au dessus de l’hypophyse et possède des liens très fournis avec les autres régions cérébrales utiles aux fonctions viscérales, autonomes et comportementales
l’éminence médiane et l’infundibulum, richement vascularisées, assurent la communication neurologique et humorale entre l’hypothalamus et l’hypophyse (figure 3)
la partie postérieure de l’hypophyse (posthypophyse ou neurohypophyse) joue le rôle de réservoir pour la vasopressine et l’oxytocine qui sont sécrétées par. l’hypothalamus
la partie antérieure de la glande pituitaire (antéhypophyse ou adénohypophyse) sécrète plusieurs hormones : les gonadotrophines, fsh (follicle-stimulating hormone ou hormone folliculo-stimulante) et lh (luteinizing hormone ou hormone lutéinisante), l’acth, la prolactine, la gh et la tsh
les gonadotrophines

les cellules gonadotropes antéhypophysaires sécrétent les gonadotrophines lh et fsh
ce sont des glycoprotéines qui interviennent dans la régulation de la production d’androgènes
la majorité des cellules gonadotropes peuvent sécréter les deux gonadotrophines qui contiennent toutes les deux une chaîne a et une chaîne b
les chaînes a sontcomposées de 96 acides aminés et sont identiques pour fsh, lh, tsh et hcg
la chaîne b est

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every nes title coming to the nintendo switch online that’s been announced so far:
these are the games nintendo will add to the service in the coming months:
naturally, you’ll lose access to the games if you let your nintendo switch online subscription lapse
but you should know that you’ll also lose access to your nes library if your console is disconnected from the internet for more than a week
nintendo says the console needs to check in with the service every seven days to maintain access
that isn’t an issue with games downloaded from xbox live’s games with gold or playstation plus
not content with the nes library of classic games? if you’re willing to jump through a couple of hoops, you can get a few more options
this is a little convoluted, but bear with us: players who make a second nintendo account and assign it « japan » as the region can create a second profile on their switch with access to the japanese eshop
this will let you buy and download any game released digitally in japan — including the « family computer » nintendo switch online app
basically, it’s the exact same thing as the nes app detailed above, but filled with japanese games
most of the games on the family computer app are the same as on its international counterpart, but there are a few key differences in some titles
the japanese version of the legend of zelda, for instance, has a more complex soundtrack — offering richer music with more audio channels and instruments than the us version
that’s because in japan, zelda made its debut on the famicom disk system, an expansion that never made it to the nes outside of its home country
did you know that the japanese version of super mario bros
3 isslightly harder? it is
when mario gets damaged in a tanooki suit, hedrops all the way back down to small mario in that version of the game
we can expect more games with differences, too: metroid, due on the system in november, was also a disk system game
it’s a small bonus, but worth it for fans that want to see how some of these games were changed when they came overseas
access to online multiplayer gaming is the main selling point of most console subscription services
just like with xbox live and playstation plus, subscribing to nintendo switch online allows you to play games like mario kart 8 deluxe, arms and splatoon 2 and the upcoming super smash bros
and, as mentioned above, online play is also enabled for the nintendo switch online service’s library of classic games — just in case you want to relive the torture of waiting for player 1 to die before taking your turn in super mario bros
at least one favorite online multiplayer game will work without a subscription
fortnite  will be playable onlineeven if you don’t have an active online subscription
there may be other exceptions to the rule, presumably for games that feature online multiplayer exclusively
nintendo hasn’t made a full list available yet
if you wanted to back up your save data on a nintendo wii, wii u or 3ds, you needed to transfer it to an sd card
on the nintendo switch, that isn’t an option
if your system is lost, stolen or broken, all the hours you sunk into the legend of zelda: breath of the wildwill be lost forever
nintendo switch online’s save data cloud feature aims to change that
for nintendo switch online subscribers, game data will automatically be backed up to nintendo servers if you have an internet connection
if you sign in to your account on a new console, you’ll be able to download that data and pick up right where you left off
it’s an easy, simple way to protect the time you’ve invested in nintendo switch games
unfortunately, there’s a catch
in order to prevent save scumming and cheating in online games, certain titles aren’t compatible with this feature
on the surface, that seems to make sense — we can’t have players hacking their pokemon let’s go: pikachu and eevee save data to cheat — but it means that competitive multiplayer games with a single-player component aren’t protected
if you lose your switch and want to pick up where you left off in splatoon 2’s single-player campaign, for instance, you’ll be out of luck
nintendo also says it can’t guarantee the data will stick around if you cancel your subscription
early wording on how long the data stuck around was frustratingly vague
recently, the company clarified: explaining to ign that if you cancel, you have six months to resubscribe before your cloud data is potentially deleted
that’s the same amount of time sony gives playstation plus users
online multiplayer is great, but without the ability to talk to other players, it’s a weirdly solitary social experience
that’s why voice chat is so important
unfortunately, nintendo’s solution to voice chat is
most game consoles allow you to plug a headset into the console’s usb port or audio input jack and talk to players directly through the game
but most nintendo switch games that support voice chat require the user to piggyback off of a smartphone by using the nintendo switch online smartphone app
it’s a convoluted and weird experience
to chat with other players in splatoon 2, for instance, you’ll need to download the app on your phone ,

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