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de stimuler les caractères sexuels secondaires pour aboutir à un phénotype masculin normal [114] et d’entraîner les modifications comportementales nécessaires au rôle de l’homme dans la reproduction [23]
la testostérone, hormone mâle sécrétée par le testicule, est l’androgène majeur qui exerce une action quasi-ubiquitaire dans l’organisme de l’homme, directement ou par l’intermédiaire de sa bioconversion en un androgène plus puissant, la dihydrotestostérone (dht) ou en un oestrogène puissant, l’oestradiol (e2)
le maintien d’un niveau approprié d’androgènes impose une production qui équilibre l’épuration métabolique et l’excrétion
la testostérone est le principal androgène circulant
elle est produite de. façon quasi-exclusive (plus de 95%) par les cellules de leydig du testicule, situées autour et entre les tubes séminifères, qui représentent 5% du volume de la glande [153]
le nombre maximum de cellules de leydig, atteint peu après 20 ans, est de 500 millions par testicule [121]
la sécrétion globale de testostérone est de 5 à 7,5 mg/24h chez l’homme adulte normal [185]
des androgènes sont également synthétisés en faibles quantités par la surrénale et en quantités infinitésimales par le cerveau [10, 83] où l’action locale pourrait cependant être importante
le contenu en testostérone du. testicule de l’homme adulte est d’environ 1µg/g de testicule, ce qui montre que la quasi-totalité de la testostérone secrétée est libérée dans la circulation [193]
le précurseur des androgènes est le cholestérol
les cellules de leydig peuvent en assurer la synthèse à partir de l’acétate, mais elles utilisent surtout le cholestérol extrait des lipoprotéines plasmatiques, et notamment de la fraction de faible densité (ldl) [140], mais aussi celui des membranes cellulaires (figure 1)
le cholestérol (c27) est transporté vers les

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not require a nintendo switch online subscription to play
nintendo’s first, and so far only, piece of software that is exclusive to online subscribers is essentially the netflix of 30-year-old video games
the app contains a library of games originally released on the nintendo entertainment system, with 20 titles available at launch and more to be added each month
the experience of playing these games — which so far includes usual nintendo suspects like super mario bros 3, the legend of zelda and donkey kong, plus some third party fare like river city ransom and ghosts 'n goblins — is extremely similar to using the previously released nes classic mini, except you can play the games anywhere
nes games look and play great on the switch, and you can even take them online
for two-player games you can of course hand one of the switch joy-cons to another player for some instant mario bros
or balloon fight action, but interestingly you can also connect to a friend over the internet to play these ancient games together
in addition to chatting while you play via the phone app, you can use your controller to move a little hand around the screen, pointing out secrets or applauding when your friend finds a hidden stash of coins (or when they fall down a pit, if you want to be sarcastic)
it's a quirky touch, but a singular one among online gaming services
of course even with added online features these old games seem a bit paltry compared to what you get with xbox live gold or playstation plus: several relatively recent full games every month
the true value of nintendo's offering will only become apparent over time
will it add quality games every month to eventually amass a truly worthwhile collection of classics, or will it drip feed mediocre titles while removing older ones from the service? for now, i've been having fun revisiting some of these retro goodies
finally, this is the most pragmatic part of the subscription and will likely be of interest to the most people, if only because nintendo is otherwise so behind the times when it comes to securing user data
previously all save data associated with your switch games was held on the console with no way to move it to a pc, usb key or online server
this meant that if you broke or lost your switch you could lose hundreds of hours of progress
this is out of step with the way other players in the industry do things
microsoft automatically uploads all user saves to the cloud for free, while sony allows all playstation gamers to move their saves to usb storage, with paying plus customers able to access cloud storage
with switch online, nintendo is providing a way for paying customers to get some peace of mind about their epic breath of the wild save data, providing a strong incentive to sign up
finally, a way to keep all your mario odyssey moons safe
cloud saves on switch are automatic and completely painless
whenever you update a save on your console, it's sent to the cloud to update the online version
if you get a new switch or are signed in on someone else's machine, you can pull the cloud save down whenever you like
as long as you stay a paying subscriber, your data will always be available online so you don't need to worry about a drowned or crushed console erasing it from existence
one downside is that nintendo says it will not enable the functionality for every game
so far the only games i've seen that do not use cloud saves are fortnite and splatoon 2
this is understandable in the case of the former, as all your progress is stored online anyway
in splatoon's case, nintendo says being able to store and restore saves could allow players to cheat and gain an advantage online, but it still sucks that you could lose all your gear and single-player progress
overall the nintendo switch online service has some shortcomings compared to its competitors, but it's also a fraction of the price
the online experience, retro games and cloud saves are all solid offerings, if not industry-leading, and it will all likely get stronger as time goes on
nintendo also claims that there will be « exclusive offers » for members only, but it hasn't exactly

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