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and drug administration (fda) has instructed testosterone gel manufactures to issue a “black box” warning regarding the potential for skin-to-skin transfer
60 this is a consequence of secondary exposure of children ranging in age from nine months to five years that were reported to the fda
adverse events reported in these children included enlargement of the genitalia, premature pubarche, advanced bone age, and aggressive behavior
overall, covering the application site with clothing seems to minimize the risk. of testosterone transfer during skin-to-skin contact
even though there is paucity of cases reporting inter-personal transfer, the risk of transfer to women and children is possible
hence, patient education is crucial
the goal of testosterone therapy should be to restore serum testosterone levels to the mid-normal range
in men receiving transdermal gel, testosterone level should be measured after patient has been on treatment for one to two weeks, ideally between two and six hours after gel application
initial. monitoring for symptom relief (improvement in libido, erectile function, energy and well being) should be performed three months after initiation of therapy
failure to

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and begin chatting with friends seems nigh barbaric in this day and age, and is something nintendo will need to eventually rectify if it ever wants to engage a crowd of serious online gamers
and while nintendo is promoting a smartphone app that enables many social and game features as one of the perks of nintendo switch online – it’s the same one used for voice chat – it seems a bit primitive to force players to use a separate device to get the full online experience
kids especially shouldn’t require access to a smartphone to view things like game stats and maps
it’s worth noting, too, that while support for storing saved game files to the cloud is a nice addition, the fact that these files might disappear if your subscription lapses is disturbing
plus, not all games are supported
if you ever plan to delete saved game files locally on your switch thinking they’re safe in the cloud, you’d be wise to first check to see if they’re saved online
so while players really oughtn’t be against paying a low annual fee for the ability to play games online – it is, after all, an ongoing expense for the hardware maker – they’ve every right to feel a little peeved that nintendo’s initial offering is lagging behind its competitors
if your family plays online-oriented switch games like splatoon 2, then a nintendo switch online subscription is, as expected, a must in order to keep playing
but players who choose to petition nintendo for a richer and more comprehensive online service aren’t out of line
nintendo’s first kick at a subscription service for online play is undeniably middling, but at least it’s cheap
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by rachel kaser —in gaming
nintendo today revealed the switch has now sold over 8
7 million units at the 21-month mark in the us, more than both the playstation 4 and the xbox one did when they were the same “age
” given how little we know about the sales of at least one of the consoles past that mark, this might be the last time we get to compare the three reliably
the information comes from data analysis company the npd group, which tracks video game sales
the little hybrid console also outsold one of its predecessors, the nintendo wii, within the same timeframe, and this doesn’t even take into account sales in japan for all three consoles
nintendo of america’s senior vp of sales, the aptly named doug bowser, said:
we are thrilled to see such a strong reaction from consumers in the second holiday season for nintendo switch
we’re looking forward to delivering more excitement and smiles to our fans in the coming year and beyond
unfortunately, this will probably be the last milestone by which we can compare the three consoles simultaneously
microsoft stopped releasing official xbox one sales figures ages ago — just a year after its release, in fact
we’ve been able to cobble together estimates of the console’s sales ever since then — most notably when someone at ea let slip the console had only sold half as much as the ps4 earlier this year — but any comparisons of the three consoles would be a little dubious after this point
according to nintendo, smash bros ultimate is now the fastest-selling switch game ever, with 3 million units sold in 11 days on the market
that should come as a surprise to no one, though — smash bros 4 and brawl were among the top-selling titles on each of the last three nintendo consoles
it’s an impressive number, though it’s still dropped on the charts in favor of red dead redemption 2 this month
the company did share promising news, that being that nintendo hardware unit and dollar sales are their highest annual since 2011
given that nintendo launched its incredibly successful 3ds in 2011, it’s probably no surprise it’s the year the company is most hoping to replicate
read next:let’s stop worshipping silicon valley in 2019
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