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years and underwent biopsies because of rising psa values
the third subject was 53 years old and had a biopsy 60 days post-treatment because of an asymmetrical prostate on digital exam
mean ipss scores. were not increased from baseline
although short-term studies27,28,42 using androgel or testim have reported no cases of prostate cancer, one year30 and three year26 extensions of these studies have documented prostate cancer. in a small number of subjects
in both short and long-term testosterone gel studies, psa elevations of 4 ng/ml or greater have occurred only in a minority of individuals and many of them have either had normal psa values on repeat measurements or normalization of psa on discontinuation of testosterone or negative biopsies (in subjects who had persistent elevations in psa despite treatment. discontinuation)
26–28 meikle and colleagues showed in a one-year study of physiological testosterone replacement in hypogonadal men that psa levels remained within the normal range, and that none of the subjects developed benign prostatic hyperplasia during therapy
there is debate regarding cases of prostate cancer that are detected in trials involving long-term testosterone administration
close monitoring of psa in these trials, the heightened awareness of the investigators, and the rate of referral to a urologist for prostate biopsy be accountable for the increased detection of prostate cancer
there is also a concern that testosterone therapy may unmask asymptomatic occult prostate cancer
there still remains considerable uncertainty whether testosterone administration can

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and xbox one, nintendo bizarrely claimed that the move was to stop players tampering with online save files to retrieve lost items or move back up online leaderboards after falling
w hen the service launches, nintendo switch online subscribers will be able to play select retro nes games on their switch
you will be able to play up two-player local multiplayer using different joy-cons, while you will also be able to take the games online for the first time
t he initial line-up of nes games for the switch are balloon fight, baseball, donkey kong, double dragon, dr
mario, excitebike, ghosts’n goblins, gradius, ice climber, ice hockey, the legend of zelda, mario bros
, pro wrestling, river city ransom, soccer, super mario bros
3, tecmo bowl, tennis and yoshi
more nes games will be added to the service as time goes on
nintendo switch online will come with a mobile companion app that will both enable voice communication for online multiplayer (rather than a dedicated headset) and allow you to access special features for select games
splatoon 2 was cited as an example with ‘splatnet 2’ allowing you to look at your battle stats and buy new gear
n intendo switch online subscribers will also have access to offers such as exclusive products and in-game items
while nintendo were coy on further details here, one of the first offers were special nes joy-cons to play the selection of retro games
the controllers are switch compatible versions of the classic nes controllers, are wireless and can be slotted onto the side of the console to charge
only nintendo switch online subscribers can buy the two-pack of controller as it stands, at the rather eye-watering price of $59
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nintendo’s online service for the switch is here
launching in september, for $20 a year, nintendo switch online will let you play games online, access classic nintendo games and exclusive discounts, and chat with your friends in-game (well, if you have a special smartphone app)
it’s a heck of a lot cheaper than what sony and microsoft offer, but is it worth the money? let’s dive in
editor’s note: wondering if nintendo’s new online service is worth paying for? check out our full nintendo switch online review
nintendo switch online is available now
the service costs $4 per month, $8 for 3 months, or $20 for a full year
you can also get a 12-month family membership for $34
99, which allows up to eight

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