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and wakefulness
negative correlations have been reported with depression, nervousness, irritability, and anxiety
in hypogonadal men receiving androgel, positive mood parameters, such as sense of well being and energy level improved while negative parameters such as sadness and irritability decreased
the improvement in mood was observed on day 30 and was maintained with continued treatment for six42 and 36 months
26 the improvement in mood parameters was not dependent on the magnitude of increase in serum testosterone levels
in fact, once serum testosterone increased into the low normal range, maximal improvement in mood parameters was seen
thus, improvement in mood (similar to sexual. function) in response to testosterone therapy appears to be dependent on reaching a threshold of serum testosterone that lies in the low normal range
the same results were replicated with the use of testim where mood improved early after institution of treatment that was maintained for the duration of the treatment up to three months27,29 and one year
30 in a short-term study with testim, loizides and colleagues54 showed that measures of positive and negative mood improved significantly, beginning with the first week of therapy and reaching a maximal response at the second week
kuhnert and colleagues28 have reported. similar findings
the local tolerability of testosterone gel is superior to other transdermal products
in studies comparing testosterone gel with a testosterone patch, the incidence of adverse skin events has been significantly higher in the testosterone patch group
for instance, skin irritation was reported in 5
5% of subjects treated with androgel and in 66% of subjects in the testosterone patch

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nintendo fans have had it good for a long, long time
unlike xbox and playstation owners, they’ve never had to pay to play their games online
this free period, like all good things, has come to an end
with the launch of nintendo switch online–which is now live with the 6
0 system update–nintendo has begun charging for online play, although there is a free seven-day trial available to sample it first
as with xbox live gold and playstation plus, anyone who wants to get the most out of their switch will all but have to subscribe
(note: this doesn’t affect wii u or nintendo 3ds owners; online service for those systems will remain free)
and while it’s not ideal having to pay for something you used to get for nothing, you won’t have much of a choice
here’s a look at everything you need to know about nintendo switch online
first, some good news: nintendo switch online costs significantly less than the competition
while you have to pay $60 for a year’s subscription to sony and microsoft’s services, nintendo only charges $20
you can order a subscription here
here’s the breakdown of pricing for a single account holder
if you have multiple people in your house who want their own accounts, you’ll need to spring for the family plan
it costs $35 per year and allows up to eight people to play online
now let’s take a look at what you get for your money
with nintendo switch live, you won’t be able to play games like mario tennis aces, splatoon 2, and mario kart 8 deluxe online without a subscription
the same goes for third-party games like the upcoming port of diablo 3: the eternal collection
if you look at the eshop page for online first-party games like mario tennis aces, you’ll see nintendo has added a disclaimer warning that online play will require a subscription
free games like fortnite don’t have the disclaimer and can continued to be played online for free
some games, like fortnite, have voice chat built in
unfortunately, many games–including nintendo’s first-party titles–don’t
and while voice chat is a standard built-in feature for playstation plus and xbox live, that’s not the case with nintendo switch online
this feature is already in place, but to talk with other players while playing online, you need to download the nintendo switch online app (you can grab it here: ios, android)
yes, you’ll need two separate devices to play and talk to people online
if you were to lose your nintendo switch and buy a new one, all of your save data would be gone forever
but with a nintendo switch online subscription, most of your save data is backed up on nintendo’s servers
unfortunately, it’s not all sunshine and cool breezes when it comes to nintendo’s cloud saves
some games don’t support online save data, and

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