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pellets)
they are implanted into the buttocks or abdomen, and provide testosterone replacement for around six months
implants are replaced periodically, once symptoms of testosterone deficiency recur
inserting the testosterone pellets is a minor surgical procedure, requiring local anaesthetic; this is the major limitation of this method of treatment
however, men using this form of testosterone replacement are usually satisfied with the method, and are more likely to continue being treated than men using other modes of testosterone replacement
testosterone implants are not safe for use by older. men, who have an increased risk of prostate cancer
if prostate cancer is diagnosed, testosterone replacement must be stopped immediately, which cannot be done if an implant is being used
implants are also unsuitable for young men with bleeding disorders
another form of testosterone replacement must be used first, so that a doctor can be sure they will not have

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seattle mariners to a group of investors led by mobile phone businessman john stanton for $640 million
after the announcement of the mobile game super mario run in september 2016, nintendo’s stock soared to just under its recent high point after the release and success of pokémon go earlier in the year, something noted by journalists as even more significant than pokémon go, as super mario run was developed in-house by nintendo, which was not the case with pokémon go
[68] in a december 2016 interview prior to the release of super mario run, miyamoto explained that the company believed that with some of their game franchises, « the longer you continue to make a series, the more complex the gameplay becomes, and the harder it becomes for new players to be able to get into the series », and that the company sees mobile games with simplified controls, such as super mario run, not only allows them to « make a game that the broadest audience of people could play », but to also reintroduce these properties to newer audiences and draw them to their consoles
on 20 october 2016, nintendo released a preview trailer about the nx, revealing the official name to be the nintendo switch
[70] according to fils-aimé, the console gave game developers new abilities to bring their creative concepts to life by opening up the concept of gaming without limits
[71] in december 2016, nintendo released super mario run for ios devices, with the game surpassing over 50 million downloads within a week of its release
kimishima stated that nintendo would release a couple of mobile games each year from then on
in september 2017, nintendo announced a partnership with the chinese gaming company tencent to publish a global version of their commercially successful mobile game, honor of kings, for the nintendo switch
the announcement lead some to believe that nintendo could soon have a bigger footprint in china, a region where the switch is not sold and is largely dominated by tencent
[73] in november 2017, it was reported that nintendo would be teaming up with illumination entertainment, an animation division of universal pictures, to make an animated mario film
[74][75][76] in april 2018, nintendo announced that kimishima would be stepping down as company president that june, with shuntaro furukawa, former managing executive officer and outside director of the pokémon company, succeeding him
released in 1977, japan’s highest selling first generation console is nintendo’s color tv game, with over three million units sold
the nintendo entertainment system (abbreviated as nes) is an 8-bit video game console, which released in north america in 1985, and in europe throughout 1986 and 1987
the console was initially released in japan as the family computer (abbreviated as famicom) in 1983
the best-selling gaming console of its time,[79] the nes helped revitalise the us video game industry following the video game crash of 1983
[80] with the nes, nintendo introduced a now-standard business model of licensing third-party developers, authorising them to produce and distribute games for nintendo’s platform
[81] the nes was bundled with super mario bros
, one of the best-selling video games of all time, and received ports of nintendo’s most popular arcade games
nintendo also produced a limited run of the nes classic edition in 2016
the nes classic system was a dedicated console modelled after an nes with 30 built-in classic first- and third-party games from the nes library
by the end of its production in april 2017, nintendo shipped over two million units
the super nintendo entertainment system (abbreviated as the super nes or snes) is a 16-bit video game console, which was released in north america in 1991, and in europe in 1992
the console was initially released in japan in 1990 as the super famicom, officially adopting the colloquially abbreviated name of its predecessor
the console introduced advanced graphics and sound capabilities compared with other consoles at the time
soon, the development of a variety of enhancement chips which were integrated onto each new game cartridge’s circuit boards, progressed the snes’s competitive edge
while even crude three-dimensional graphics had previously rarely been seen on home consoles,[82] the super nes’s enhancement chips suddenly enabled a new calibre of games containing increasingly sophisticated faux 3d effects as seen in 1991’s pilotwings and 1992’s super mario kart
argonaut games developed the super fx chip in order to replicate 3d graphics from their earlier atari st and amiga starglider series on the super nes (more specifically, starglider 2),[83] starting with star fox in 1993
the snes is the best-selling console of the 16-bit era although having experienced a relatively late start and fierce competition from sega’s mega drive/genesis console
nintendo also released a limited run of the super nes classic edition in september 2017 through the end of the year
like the nes classic edition, the super nes classic edition is a dedicated console with 21 built-in games from its library, including the never-before-released starfox 2
the nintendo 64 was released in 1996, featuring 3d polygon model rendering capabilities and built-in multiplayer for up to four players
the system’s controller introduced the analogue stick and later introduced the rumble pak, an accessory for the controller that produces force feedback with compatible games
both are the first such features to have come to

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