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injections of testosterone (e
reandron), which are administered every 3 months, provide an alternative for men who experience the peak–trough effect
long-acting testosterone injections provide testosterone replacement for 10–14 weeks
 they are administered by injection deep into the gluteal muscle
the testosterone is released gradually into the bloodstream
for more. information on long-acting testosterone injections, see testosterone undecanoate (reandron)
transdermal testosterone patches
testosterone patches that adhere to the skin may also be suitable for long-term testosterone replacement therapy
however, the patches contain substances that increase the absorption of testosterone, and these cause skin irritation in up. to 50% of men who use them
some 10% of men stop using testosterone patches because of skin irritation
men may also discontinue use because they find the patches cosmetically displeasing
they may find other transdermal methods of administration more appropriate (e
most men require a single patch containing 5 mg of testosterone daily
the patch can be applied to the abdomen, upper arm or thigh, and should be left

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retired on 24 may 2002,[30][31] satoru iwata became first nintendo president who was unrelated to the yamauchi family through blood or marriage since its founding in 1889
in 2003, nintendo released the game boy advance sp, a redesign of the game boy advance that featured a clamshell design that would later be used in nintendo’s ds and 3ds handheld video game systems
in 2004, nintendo released the nintendo ds, its fourth major handheld system
the ds is a dual screened handheld featuring touch screen capabilities, which respond to either a stylus or the touch of a finger
former nintendo president and now chairman hiroshi yamauchi was translated by gamescience as explaining, « if we can increase the scope of the industry, we can re-energise the global market and lift japan out of depression – that is nintendo’s mission
 » regarding lukewarm gamecube sales which had yielded the company’s first reported operating loss in over 100 years, yamauchi continued: « the ds represents a critical moment for nintendo’s success over the next two years
if it succeeds, we rise to the heavens, if it fails, we sink into hell
« [34][35][36] thanks to games such as nintendogs and mario kart ds, the ds became a success
in 2005, nintendo released the game boy micro in north america, a redesign of the game boy advance
the last system in the game boy line, it was also the smallest game boy, and the least successful
in the middle of 2005, nintendo opened the nintendo world store in new york city, which would sell nintendo games, present a museum of nintendo history, and host public parties such as for product launches
the store was renovated and renamed as nintendo new york in 2016
in the first half of 2006, nintendo released the nintendo ds lite, a version of the original nintendo ds with lighter weight, brighter screen, and better battery life
in addition to this streamlined design, its prolific subset of casual games appealed to the masses, such as the brain age series
meanwhile, new super mario bros
provided a substantial addition to the mario series when it was launched to the top of sales charts
the successful direction of the nintendo ds had a big influence on nintendo’s next home console (including the common nintendo wi-fi connection),[37] which had been codenamed « revolution » and was now renamed to « wii »
[citation needed ] in august 2006, nintendo published es, a now-dormant, open source research operating system project designed around web application integration but for no specific purpose
in the latter half of 2006, nintendo released the wii as the backward-compatible successor to the gamecube
based upon intricate wii remote motion controls and a balance board, the wii inspired several new game franchises, some targeted at entirely new market segments of casual and fitness gaming
selling more than 100 million worldwide, the wii was the best selling console of the seventh generation, regaining market share lost during the tenures of the nintendo 64 and gamecube
on 1 may 2007, nintendo acquired an 80% stake on video game development company monolith soft, previously owned by bandai namco
monolith soft is best known for developing role-playing games such as the xenosaga and baten kaitos series
during the holiday season of 2008, nintendo followed up the success of the ds with the release of the nintendo dsi in japan
the system features a more powerful cpu and more ram, two cameras, one facing towards the player and one facing outwards, and had an online distribution store called dsiware
the dsi was later released worldwide during 2009
in the latter half of 2009, nintendo released the nintendo dsi xl in japan, a larger version of the dsi
this updated system was later released worldwide in 2010
in 2011, nintendo released the nintendo 3ds, based upon a glasses-free stereoscopic 3d display
in february 2012, nintendo acquired mobiclip, a france-based research and development company specialised in highly optimised software technologies such as video compression
the company’s name was later changed to nintendo european research & development
[41] during the fourth quarter of 2012, nintendo released the wii u
it sold slower than expected,[42] despite being the first eighth generation console
by september 2013, however, sales had rebounded
[clarification needed ] intending to broaden the 3ds market, nintendo released 2013’s cost-reduced nintendo 2ds
the 2ds is compatible with but lacks the 3ds’s more expensive but cosmetic autostereoscopic 3d feature
nintendo also released the wii mini, a cheaper and non-networked redesign of the wii
on 25 september 2013, nintendo announced it had purchased a

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